Infomap Cluster 5

Metabolite Network

mQTL individually significant in locus
Novel rQTL
Known rQTL

Aggregated Cluster Evidence

Significant GTEx eQTL Colocalization (P-alpha < 5e-5)

Tissue Gene P(alpha) Associated Metabolites
Heart Left Ventricle NFATC3 1.10e-05 behenoyl sphingomyelin (d18:1/22:0)*lignoceroyl sphingomyelin (d18:1/24:0)sphingomyelin (d18:0/18:0, d19:0/17:0)*sphingomyelin (d18:1/19:0, d19:1/18:0)*sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*tricosanoyl sphingomyelin (d18:1/23:0)*
Whole Blood SLC7A6 1.54e-05 behenoyl sphingomyelin (d18:1/22:0)*lignoceroyl sphingomyelin (d18:1/24:0)sphingomyelin (d18:0/18:0, d19:0/17:0)*sphingomyelin (d18:1/19:0, d19:1/18:0)*sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*tricosanoyl sphingomyelin (d18:1/23:0)*
Thyroid PLA2G15 3.73e-05 behenoyl sphingomyelin (d18:1/22:0)*lignoceroyl sphingomyelin (d18:1/24:0)sphingomyelin (d18:0/18:0, d19:0/17:0)*sphingomyelin (d18:1/19:0, d19:1/18:0)*sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*tricosanoyl sphingomyelin (d18:1/23:0)*

Genomic Context

Displaying 8 SNPs on Chr 20 for Cluster 5.

Novel rQTL (▲)
Known rQTL (▲)

Cluster Summary

137

Metabolite Ratios (rQTLs)

41

Total Unique Metabolites

0

Unnamed Metabolites

Ratios in Cluster 5

Ratio Name Novel in Cluster Driven By
1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to myristoyl dihydrosphingomyelin (d18:0/14:0)* No
1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to sphingomyelin (d17:1/14:0, d16:1/15:0)* Yes
1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* Yes
1-palmitoyl-2-stearoyl-gpc (16:0/18:0) to sphingomyelin (d18:1/14:0, d16:1/16:0)* No
behenoyl dihydrosphingomyelin (d18:0/22:0)* to sphingomyelin (d18:0/20:0, d16:0/22:0)* No
glycosyl-n-palmitoyl-sphingosine (d18:1/16:0) to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to behenoyl dihydrosphingomyelin (d18:0/22:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to behenoyl sphingomyelin (d18:1/22:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to glycosyl ceramide (d18:1/23:1, d17:1/24:1)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to glycosyl-n-stearoyl-sphingosine (d18:1/18:0) Yes
lignoceroyl sphingomyelin (d18:1/24:0) to myristoyl dihydrosphingomyelin (d18:0/14:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to n-palmitoyl-heptadecasphingosine (d17:1/16:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to n-stearoyl-sphinganine (d18:0/18:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to palmitoyl dihydrosphingomyelin (d18:0/16:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d17:1/14:0, d16:1/15:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:0/18:0, d19:0/17:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:0/20:0, d16:0/22:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/14:0, d16:1/16:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) Yes
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:1/25:0, d19:0/24:1, d20:1/23:0, d19:1/24:0)* No
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
lignoceroyl sphingomyelin (d18:1/24:0) to sphingomyelin (d18:2/23:1)* Yes
n-stearoyl-sphingosine (d18:1/18:0)* to lignoceroyl sphingomyelin (d18:1/24:0) No
n-stearoyl-sphingosine (d18:1/18:0)* to sphingomyelin (d18:1/18:1, d18:2/18:0) No
n-stearoyl-sphingosine (d18:1/18:0)* to sphingomyelin (d18:2/16:0, d18:1/16:1)* No
palmitoyl sphingomyelin (d18:1/16:0) to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
palmitoyl sphingomyelin (d18:1/16:0) to sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* Yes
palmitoyl sphingomyelin (d18:1/16:0) to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) Yes
palmitoyl sphingomyelin (d18:1/16:0) to sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* Yes
sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* to sphingomyelin (d18:2/18:1)* Yes
sphingomyelin (d17:2/16:0, d18:2/15:0)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d17:2/16:0, d18:2/15:0)* to sphingomyelin (d18:1/25:0, d19:0/24:1, d20:1/23:0, d19:1/24:0)* No
sphingomyelin (d18:1/14:0, d16:1/16:0)* to palmitoyl sphingomyelin (d18:1/16:0) No
sphingomyelin (d18:1/14:0, d16:1/16:0)* to sphingomyelin (d18:2/14:0, d18:1/14:1)* No
sphingomyelin (d18:1/14:0, d16:1/16:0)* to sphingomyelin (d18:2/16:0, d18:1/16:1)* No
sphingomyelin (d18:1/14:0, d16:1/16:0)* to sphingomyelin (d18:2/18:1)* No
sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) to sphingomyelin (d18:2/18:1)* Yes
sphingomyelin (d18:1/18:1, d18:2/18:0) to sphingomyelin (d18:0/18:0, d19:0/17:0)* No
sphingomyelin (d18:1/18:1, d18:2/18:0) to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) Yes
sphingomyelin (d18:1/18:1, d18:2/18:0) to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d18:1/18:1, d18:2/18:0) to sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* Yes
sphingomyelin (d18:1/18:1, d18:2/18:0) to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* No
sphingomyelin (d18:1/18:1, d18:2/18:0) to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
sphingomyelin (d18:1/20:0, d16:1/22:0)* to sphingomyelin (d18:2/18:1)* No
sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* to sphingomyelin (d18:2/18:1)* Yes
sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* to sphingomyelin (d18:2/24:2)* Yes
sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* to sphingomyelin (d17:2/16:0, d18:2/15:0)* No
sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* to sphingomyelin (d18:2/18:1)* No
sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* to sphingomyelin (d18:2/18:1)* Yes
sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* to sphingomyelin (d18:2/18:1)* No
sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* to sphingomyelin (d18:2/24:2)* No
sphingomyelin (d18:1/24:1, d18:2/24:0)* to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
sphingomyelin (d18:1/24:1, d18:2/24:0)* to sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* Yes
sphingomyelin (d18:1/24:1, d18:2/24:0)* to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* No
sphingomyelin (d18:2/14:0, d18:1/14:1)* to myristoyl dihydrosphingomyelin (d18:0/14:0)* No
sphingomyelin (d18:2/14:0, d18:1/14:1)* to sphingomyelin (d17:1/14:0, d16:1/15:0)* Yes
sphingomyelin (d18:2/14:0, d18:1/14:1)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d18:2/14:0, d18:1/14:1)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* No Denominator
sphingomyelin (d18:2/14:0, d18:1/14:1)* to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to behenoyl dihydrosphingomyelin (d18:0/22:0)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to glycosyl ceramide (d18:1/23:1, d17:1/24:1)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to glycosyl-n-behenoyl-sphingadienine (d18:2/22:0)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to glycosyl-n-stearoyl-sphingosine (d18:1/18:0) Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to myristoyl dihydrosphingomyelin (d18:0/14:0)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to n-palmitoyl-heptadecasphingosine (d17:1/16:0)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d17:1/14:0, d16:1/15:0)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d17:2/16:0, d18:2/15:0)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:0/18:0, d19:0/17:0)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* No
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
sphingomyelin (d18:2/16:0, d18:1/16:1)* to sphingomyelin (d18:2/23:1)* Yes
sphingomyelin (d18:2/18:1)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d18:2/18:1)* to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
sphingomyelin (d18:2/21:0, d16:2/23:0)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* No
sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)* to sphingomyelin (d18:2/24:1, d18:1/24:2)* Yes
sphingomyelin (d18:2/23:1)* to sphingomyelin (d18:2/18:1)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to glycosyl ceramide (d18:1/23:1, d17:1/24:1)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to glycosyl-n-stearoyl-sphingosine (d18:1/18:0) Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to myristoyl dihydrosphingomyelin (d18:0/14:0)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to n-palmitoyl-heptadecasphingosine (d17:1/16:0)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d17:1/14:0, d16:1/15:0)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:0/18:0, d19:0/17:0)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/14:0, d16:1/16:0)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* No
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
sphingomyelin (d18:2/24:1, d18:1/24:2)* to sphingomyelin (d18:2/23:1)* Yes
sphingomyelin (d18:2/24:2)* to sphingomyelin (d18:2/23:1)* Yes
stearoyl sphingomyelin (d18:1/18:0) to lignoceroyl sphingomyelin (d18:1/24:0) Yes
stearoyl sphingomyelin (d18:1/18:0) to sphingomyelin (d18:1/18:1, d18:2/18:0) Yes
stearoyl sphingomyelin (d18:1/18:0) to sphingomyelin (d18:2/16:0, d18:1/16:1)* Yes
stearoyl sphingomyelin (d18:1/18:0) to sphingomyelin (d18:2/18:1)* Yes
stearoyl sphingomyelin (d18:1/18:0) to sphingomyelin (d18:2/24:1, d18:1/24:2)* Yes
stearoyl sphingomyelin (d18:1/18:0) to tricosanoyl sphingomyelin (d18:1/23:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to behenoyl dihydrosphingomyelin (d18:0/22:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to glycosyl ceramide (d18:1/20:0, d16:1/22:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to myristoyl dihydrosphingomyelin (d18:0/14:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to n-palmitoyl-heptadecasphingosine (d17:1/16:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d17:1/14:0, d16:1/15:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:0/18:0, d19:0/17:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:0/20:0, d16:0/22:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/14:0, d16:1/16:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/19:0, d19:1/18:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/20:0, d16:1/22:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/22:2, d18:2/22:1, d16:1/24:2)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:1/25:0, d19:0/24:1, d20:1/23:0, d19:1/24:0)* No
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:2/21:0, d16:2/23:0)* Yes
tricosanoyl sphingomyelin (d18:1/23:0)* to sphingomyelin (d18:2/23:1)* Yes