1-stearoyl-2-arachidonoyl-gpi (18:0/20:4) to 1-stearoyl-2-arachidonoyl-gpc (18:0/20:4)

Numerator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpc (18:0/20:4)
Metabolite Accession: GCST90200685
Name: 1-stearoyl-2-arachidonoyl-gpc (18:0/20:4)
Hmdb Id: HMDB0008048
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSVRFUPOQYJOOZ

Associated Genomic Regions

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.237
Position:
54677189
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-14.989
Reference Allele:
C
-log10(P):
-115.274
MAF:
0.434
Beta (Num):
-0.174
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.063
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylinositol acyl-chain remodeling (Land's cycle).4[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.7[1]

Ratio Explanation:

The ratio reflects the activity of MBOAT7, which remodels phospholipids, influencing the abundance of its product, 1-stearoyl-2-arachidonoyl-gpi, relative to other membrane phospholipids like GPC.4[1], 8[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 function alters the cellular pool of phosphatidylinositols, which are critical signaling molecules for platelet production and activation, thus plausibly affecting platelet count.10[1], 11[2], 12[3] MBOAT7 variants are also associated with altered alkaline phosphatase levels, a liver enzyme.13[4], 14[5]

Phenotype Driver:

Metabolite-centric:1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data