1-stearoyl-2-arachidonoyl-gpi (18:0/20:4) to 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)

Numerator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Metabolite Accession: GCST90200692
Name: 1-palmitoyl-2-arachidonoyl-gpc (16:0/20:4n6)
Hmdb Id: HMDB0007982
Super Pathway: NA
Sub Pathway: NA
Inchikey: IIZPXYDJLKNOIY

Associated Genomic Regions

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
-0.241
Position:
54677189
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-15.451
Reference Allele:
C
-log10(P):
-122.328
MAF:
0.434
Beta (Num):
-0.174
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.067
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylinositol (PI) biosynthesis

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio reflects the relative activity of MBOAT7, which produces the numerator 1-stearoyl-2-arachidonoyl-gpi, against the general availability of other phospholipids like the denominator.5[1], 6[2], 7[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 function, potentially influenced by genetic factors, can decrease the synthesis of 1-stearoyl-2-arachidonoyl-gpi, altering lipid metabolism and potentially impacting platelet count and alkaline phosphatase levels, although the direct causal link is still under investigation.8[1], 9[2]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data