palmitoylcarnitine (c16) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.181
Position:
102075479
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
9.191
Reference Allele:
G
-log10(P):
-44.692
MAF:
0.176
Beta (Num):
0.053
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect the balance between fatty acid beta-oxidation and de novo lipogenesis, influenced by carnitine uptake via SLC22A5 and desaturation by SCD.1[1], 7[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired SLC22A5 function can reduce palmitoylcarnitine formation and fatty acid oxidation, potentially contributing to lipid metabolism disorders and atherosclerosis, phenotypes also linked to altered palmitoleate levels.2[1], 10[2], 7[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data