3-hydroxymyristate to palmitoleate (16:1n7)

Numerator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.142
Position:
102075479
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
9.917
Reference Allele:
G
-log10(P):
-51.708
MAF:
0.176
Beta (Num):
0.013
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.128
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Lipopolysaccharide metabolism

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio reflects the activity of Stearoyl-CoA Desaturase (SCD), where a higher ratio suggests increased conversion of saturated to monounsaturated fats.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SCD gene expression is linked to atherosclerosis, hypercholesterolemia, and other lipidaemias. Altered SCD activity, reflected by the ratio, likely contributes to these cardiovascular and metabolic phenotypes by influencing lipid composition and metabolism.1[1], 3[2]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data