3-hydroxydecanoate to stearate (18:0)

Numerator Metabolite

Structure of 3-hydroxydecanoate
Metabolite Accession: GCST90199693
Name: 3-hydroxydecanoate
Hmdb Id: HMDB0002203
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYSSBMZUBSBFJL

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.227
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-16.112
Reference Allele:
G
-log10(P):
-132.808
MAF:
0.318
Beta (Num):
-0.210
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2]

Ratio Explanation:

Elevated 3-hydroxydecanoate relative to stearate may indicate increased fatty acid oxidation or impaired fatty acid synthesis, a process influenced by THEM4's thioesterase activity.1[1], 2[2], 4[3], 5[4], 3[5]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data