trigonelline (n'-methylnicotinate) to 1-methylxanthine

Numerator Metabolite

Structure of trigonelline (n'-methylnicotinate)
Metabolite Accession: GCST90199696
Name: trigonelline (n'-methylnicotinate)
Hmdb Id: HMDB0000875
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWNNZCOKKKDOPX

Denominator Metabolite

Structure of 1-methylxanthine
Metabolite Accession: GCST90199763
Name: 1-methylxanthine
Hmdb Id: HMDB0010738
Super Pathway: NA
Sub Pathway: NA
Inchikey: MVOYJPOZRLFTCP

Associated Genomic Regions

Region: rs1495743

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Clumped rQTL variant

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SNP Summary

Chr:
8
Beta (Ratio):
0.375
Position:
18273300
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
21.017
Reference Allele:
C
-log10(P):
-224.132
MAF:
0.226
Beta (Num):
0.007
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.368
SE (Den):
0.019
No CNV overlap
rQTL cluster:
85
Reaction Distance:
NA
Closest Genes:
NAT2 PSD3 NAT1 ASAH1 PCM1

LLM Analysis

Numerator Metabolite Explanation:

Nicotinic acid metabolism, Pyridine nucleotide cycle4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Purine metabolism, Caffeine metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio of trigonelline to 1-methylxanthine may reflect altered xenobiotic and purine metabolism, influenced by NAT2 activity, which is linked to bladder cancer risk.1[1], 10[2], 11[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in NAT2, particularly those leading to a slow acetylator phenotype, are associated with an increased risk of bladder cancer.1[1], 12[2], 13[3] This altered NAT2 activity may influence the metabolism of various compounds, reflected in the trigonelline to 1-methylxanthine ratio, and contribute to bladder cancer development.10[4], 11[5]

Phenotype Driver:

Gene-centric:NAT2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data