dodecanedioate (c12-dc) to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Structure of dodecanedioate (c12-dc)
Metabolite Accession: GCST90199697
Name: dodecanedioate (c12-dc)
Hmdb Id: HMDB0000623
Super Pathway: NA
Sub Pathway: NA
Inchikey: TVIDDXQYHWJXFK

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.352
Position:
47389613
SE (Ratio):
0.033
Effect Allele:
T
Z-score (Ratio):
-10.763
Reference Allele:
C
-log10(P):
-60.529
MAF:
0.128
Beta (Num):
-0.151
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.201
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, Glycine conjugation.7[1]

Ratio Explanation:

The ratio may reflect the balance between fatty acid omega-oxidation and xenobiotic conjugation, a process potentially influenced by the missense variant in CYP4B1.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link not applicable as no phenotype is associated with the ratio.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data