3-hydroxylaurate to adrenate (22:4n6)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.137
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-10.138
Reference Allele:
G
-log10(P):
-53.941
MAF:
0.318
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.031
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs174546

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.172
Position:
61569830
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
13.050
Reference Allele:
C
-log10(P):
-87.947
MAF:
0.339
Beta (Num):
-0.011
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.183
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1]

Ratio Explanation:

The ratio of 3-hydroxylaurate (a beta-oxidation intermediate) to adrenate (a polyunsaturated fatty acid) may reflect the balance between fatty acid degradation and synthesis.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity can decrease adrenate synthesis, altering the ratio.5[1], 1[2] This dysregulation of fatty acid metabolism is linked to phenotypes like cholelithiasis, type 2 diabetes, and inflammatory conditions, as FADS enzymes modulate inflammatory pathways and lipid profiles associated with these diseases.6[3], 7[4], 8[5], 9[6], 10[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data