3-hydroxylaurate to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs968567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.302
Position:
61595564
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-14.631
Reference Allele:
C
-log10(P):
-109.942
MAF:
0.179
Beta (Num):
-0.024
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.278
SE (Den):
0.021
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation

Denominator Metabolite Explanation:

Omega-3 polyunsaturated fatty acid synthesis

Ratio Explanation:

The ratio contrasts fatty acid oxidation (numerator) against FADS2-mediated PUFA synthesis (denominator), indicating a potential shift in fatty acid metabolism.1[1], 2[2], 4[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS2 alters polyunsaturated fatty acid (PUFA) synthesis, which is reflected in the ratio. This dysregulation of pro- and anti-inflammatory lipid mediators likely contributes to the observed inflammatory phenotypes like asthma and dermatitis, which have strong links to PUFA metabolism.5[1], 6[2], 7[3], 8[4], 9[5]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data