3-hydroxylaurate to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.123
Position:
151879761
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-9.957
Reference Allele:
G
-log10(P):
-52.102
MAF:
0.318
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs174581

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.131
Position:
61606683
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
10.902
Reference Allele:
G
-log10(P):
-62.046
MAF:
0.350
Beta (Num):
-0.006
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.137
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FADS3 FEN1 TMEM258

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects the balance between fatty acid synthesis and the production of long-chain polyunsaturated fatty acids, regulated by FADS enzymes.1[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are associated with altered LC-PUFA levels, impacting lipid metabolism and inflammation.12[1], 13[2], 14[3] This can influence the risk for dyslipidemia, type 2 diabetes, asthma, and cholelithiasis.15[4], 16[5], 17[6], 18[7], 19[8], 20[9], 21[10], 22[11]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data