3-hydroxylaurate to octanoylcarnitine (c8)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of octanoylcarnitine (c8)
Metabolite Accession: GCST90199720
Name: octanoylcarnitine (c8)
Hmdb Id: HMDB0000791
Super Pathway: NA
Sub Pathway: NA
Inchikey: CXTATJFJDMJMIY

Associated Genomic Regions

Region: rs17843929

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
0.199
Position:
159637113
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
12.775
Reference Allele:
C
-log10(P):
-84.383
MAF:
0.263
Beta (Num):
0.008
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.191
SE (Den):
0.017
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 FNIP2 RXFP1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, Mitochondrial fatty acid synthesis4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation7[1], 8[2]

Ratio Explanation:

The ratio reflects the activity of ACADM; reduced function leads to the accumulation of upstream metabolites like octanoylcarnitine relative to downstream products.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data