3-hydroxylaurate to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.114
Position:
102075479
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
8.655
Reference Allele:
G
-log10(P):
-39.852
MAF:
0.176
Beta (Num):
0.002
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.112
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation4[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis5[1]

Ratio Explanation:

The ratio of 3-hydroxylaurate to 5-dodecenoate may reflect the balance between fatty acid breakdown and synthesis, potentially influenced by SCD activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SCD gene activity influences the balance of fatty acids.1[1], 2[2], 3[3] Altered ratios are associated with coronary atherosclerosis, hypercholesterolemia, and cholelithiasis, likely due to downstream effects on lipid metabolism and inflammation.6[4], 7[5], 8[6]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data