3-hydroxylaurate to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs1387833

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.129
Position:
151907073
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
-9.649
Reference Allele:
G
-log10(P):
-49.058
MAF:
0.361
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.024
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D S100A11

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid metabolism/biosynthesis.5[1], 6[2], 7[3]

Ratio Explanation:

Increased ratio of 3-hydroxylaurate to linolenate may reflect altered mitochondrial fatty acid metabolism, potentially influenced by THEM4's thioesterase activity on acyl-CoA substrates.1[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

THEM4's role in fatty acid metabolism may influence gut inflammation.8[1] Altered fatty acid profiles, potentially modulated by THEM4, are associated with diverticular disease, an inflammatory condition of the intestine.8[2], 9[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data