3-hydroxylaurate to laurylcarnitine

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs6684114

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.145
Position:
151928715
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-10.852
Reference Allele:
A
-log10(P):
-61.505
MAF:
0.315
Beta (Num):
-0.101
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.044
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

Region: rs4781721

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
16
Beta (Ratio):
0.111
Position:
16107277
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
8.621
Reference Allele:
A
-log10(P):
-39.551
MAF:
0.384
Beta (Num):
0.018
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.093
SE (Den):
0.015
No CNV overlap
rQTL cluster:
33
Reaction Distance:
NA
Closest Genes:
ABCC1 FOPNL ABCC6 MYH11 NOMO3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid transport, beta-oxidation

Ratio Explanation:

Higher 3-hydroxylaurate to laurylcarnitine may indicate altered fatty acid oxidation, potentially influenced by THEM4's thioesterase activity or ABCC1's transport function.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The ABCC1 transporter, present on red blood cells, is associated with MCH and MCHC.4[1], 5[2], 6[3] Altered ABCC1 function could impact red blood cell properties and fatty acid metabolism, leading to changes in the MCH and MCHC.

Phenotype Driver:

Gene-centric:ABCC1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data