3-hydroxylaurate to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.133
Position:
151879761
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-9.175
Reference Allele:
G
-log10(P):
-44.543
MAF:
0.318
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.027
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1]

Denominator Metabolite Explanation:

Omega-6 PUFA biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect the balance between fatty acid oxidation (numerator) and omega-6 PUFA biosynthesis (denominator), potentially modulated by THEM4's regulation of acyl-CoA pools.3[1], 4[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic regulation of THEM4 likely influences the balance of fatty acid oxidation and PUFA synthesis, as reflected in the ratio, but without an associated phenotype, a causal link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data