3-hydroxylaurate to cis-4-decenoylcarnitine (c10:1)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of cis-4-decenoylcarnitine (c10:1)
Metabolite Accession: GCST90199880
Name: cis-4-decenoylcarnitine (c10:1)
Hmdb Id: HMDB0013205
Super Pathway: NA
Sub Pathway: NA
Inchikey: GOOOCIIXFLVRAG

Associated Genomic Regions

Region: rs10788818

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.152
Position:
151892199
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-9.161
Reference Allele:
C
-log10(P):
-44.415
MAF:
0.371
Beta (Num):
-0.109
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.043
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio reflects altered mitochondrial fatty acid metabolism.8[1], 9[2] THEM4 activity influences the availability of acyl-CoAs for both oxidation and carnitine conjugation.1[3], 7[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered THEM4 expression, colocalized with diverticular disease, likely modifies fatty acid metabolism.1[1], 10[2] This metabolic dysregulation, potentially influencing inflammatory pathways, may contribute to the pathophysiology of diverticular disease, which is associated with inflammation and diet.11[3], 12[4]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data