3-hydroxylaurate to margaroylcarnitine (c17)*

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of margaroylcarnitine (c17)*
Metabolite Accession: GCST90199929
Name: margaroylcarnitine (c17)*
Hmdb Id: HMDB0006210
Super Pathway: NA
Sub Pathway: NA
Inchikey: DWSFAVOTORHAAL

Associated Genomic Regions

Region: rs6685187

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.163
Position:
151858888
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-8.941
Reference Allele:
G
-log10(P):
-42.401
MAF:
0.398
Beta (Num):
-0.106
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.057
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC LINGO4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.3[1], 4[2], 5[3], 6[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

This ratio reflects the balance between medium-chain (C12) and odd-chain (C17) fatty acid oxidation, which may be modulated by THEM4's activity on long-chain acyl-CoAs.11[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype data provided. The eQTL for THEM4 suggests its expression level, which regulates long-chain fatty acid oxidation, influences the ratio of these two fatty acid oxidation intermediates.1[1], 2[2], 11[3]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data