3-hydroxylaurate to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs2999545

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.142
Position:
151904146
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-11.618
Reference Allele:
T
-log10(P):
-70.175
MAF:
0.388
Beta (Num):
-0.103
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.039
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation6[1], 7[2]

Ratio Explanation:

The ratio of 3-hydroxylaurate to myristoleoylcarnitine may reflect the balance between different steps or locations (mitochondrial vs. peroxisomal) of fatty acid oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No direct link between the THEM4 gene, the specified metabolite ratio, and a phenotype can be established from the provided information.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data