3-hydroxylaurate to pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Metabolite Accession: GCST90200101
Name: pimeloylcarnitine/3-methyladipoylcarnitine (c7-dc)
Hmdb Id: HMDB0013328
Super Pathway: NA
Sub Pathway: NA
Inchikey: NTBUXPPQHCFLOM

Associated Genomic Regions

Region: rs10788817

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.205
Position:
151882856
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-9.261
Reference Allele:
G
-log10(P):
-45.349
MAF:
0.398
Beta (Num):
-0.107
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.098
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (dicarboxylate), amino acid degradation.6[1], 7[2], 8[3]

Ratio Explanation:

A higher ratio may suggest increased fatty acid synthesis or turnover (numerator) relative to the degradation of dicarboxylic acids or certain amino acids (denominator).

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype is provided, so a causal link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data