3-hydroxylaurate to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.146
Position:
151879761
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-10.039
Reference Allele:
G
-log10(P):
-52.932
MAF:
0.318
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.040
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (acylcarnitine).6[1], 7[2]

Ratio Explanation:

This ratio may indicate the relative activity of fatty acid oxidation pathways, potentially influenced by the efficiency of carnitine transport mediated by SLC22A4.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A4 can alter its transporter function, which is associated with inflammatory diseases like rheumatoid arthritis and Crohn's disease.8[1], 3[2], 9[3] This systemic inflammation likely drives the observed changes in hematological traits, with the metabolite ratio being a secondary downstream marker.

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data