3-hydroxylaurate to glycine conjugate of c10h12o2*

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs10788817

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.210
Position:
151882856
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
-9.107
Reference Allele:
G
-log10(P):
-43.913
MAF:
0.398
Beta (Num):
-0.107
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.103
SE (Den):
0.018
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation

Denominator Metabolite Explanation:

Glycine conjugation pathway

Ratio Explanation:

The ratio may reflect the balance between fatty acid oxidation (numerator) and detoxification of acyl-CoAs via glycine conjugation (denominator), potentially modulated by THEM4.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype data was provided, preventing the establishment of a causal link between the THEM4 gene, the metabolic ratio, and any specific phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data