3-hydroxylaurate to palmitoleate (16:1n7)

Numerator Metabolite

Structure of 3-hydroxylaurate
Metabolite Accession: GCST90199700
Name: 3-hydroxylaurate
Hmdb Id: HMDB0000387
Super Pathway: NA
Sub Pathway: NA
Inchikey: MUCMKTPAZLSKTL

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.115
Position:
151879761
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
-9.389
Reference Allele:
G
-log10(P):
-46.557
MAF:
0.318
Beta (Num):
-0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.010
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.6[1]

Ratio Explanation:

This ratio may reflect the balance between fatty acid oxidation (3-hydroxylaurate) and biosynthesis (palmitoleate), potentially modulated by THEM4's thioesterase activity on acyl-CoA intermediates.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was associated with this ratio, so no causal link between THEM4, the metabolic ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data