3-hydroxysebacate to n-oleoyltaurine

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.314
Position:
46870761
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
-14.090
Reference Allele:
C
-log10(P):
-102.133
MAF:
0.207
Beta (Num):
-0.075
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.239
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid amide metabolism.1[1], 5[2]

Ratio Explanation:

This ratio reflects the balance between omega-oxidation and fatty acid amide catabolism; lower FAAH activity could increase n-oleoyltaurine, decreasing the ratio.1[1], 3[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in FAAH could alter its activity, affecting the 3-hydroxysebacate to n-oleoyltaurine ratio, a potential biomarker of metabolic state; however, no phenotype link is established from the provided data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data