3-hydroxysebacate to 3-hydroxyhexanoate

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Structure of 3-hydroxyhexanoate
Metabolite Accession: GCST90200012
Name: 3-hydroxyhexanoate
Hmdb Id: HMDB0061652,HMDB0010718
Super Pathway: NA
Sub Pathway: NA
Inchikey: HPMGFDVTYHWBAG

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.296
Position:
47389613
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-13.743
Reference Allele:
C
-log10(P):
-97.293
MAF:
0.123
Beta (Num):
-0.246
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.050
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.8[1], 9[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.10[1], 11[2]

Ratio Explanation:

This ratio may reflect the balance between omega-oxidation (producing 3-hydroxysebacate) and beta-oxidation pathways, potentially influenced by the activity of CYP4 family enzymes.12[1], 8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was provided; therefore, a link between the genetic factors, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data