3-hydroxysebacate to 4-hydroxyphenylacetylglutamine

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Structure of 4-hydroxyphenylacetylglutamine
Metabolite Accession: GCST90200106
Name: 4-hydroxyphenylacetylglutamine
Hmdb Id: HMDB0006061
Super Pathway: NA
Sub Pathway: NA
Inchikey: CYRKYXZJUIBBJX

Associated Genomic Regions

Region: rs56078223

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.199
Position:
151898843
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
-8.506
Reference Allele:
T
-log10(P):
-38.558
MAF:
0.291
Beta (Num):
-0.108
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.091
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Tyrosine metabolism, gut microbe metabolism.6[1], 7[2]

Ratio Explanation:

The ratio likely reflects THEM4's modulation of fatty acid omega-oxidation (numerator) relative to the unrelated gut-derived tyrosine metabolite (denominator).

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation influencing THEM4 expression is colocalized with diverticular disease. Altered lipid metabolism or inflammatory responses modulated by THEM4 may contribute to the pathogenesis of intestinal diverticular disease, a condition influenced by diet and inflammation.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data