3-hydroxysebacate to 5-dodecenoylcarnitine (c12:1)

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Metabolite Accession: GCST90200151
Name: 5-dodecenoylcarnitine (c12:1)
Hmdb Id: HMDB13326
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.167
Position:
151879761
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-8.607
Reference Allele:
G
-log10(P):
-39.428
MAF:
0.314
Beta (Num):
-0.106
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.061
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Ratio Explanation:

The ratio may reflect a shift between mitochondrial fatty acid oxidation pathways, but the direct relationship is not established.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

The THEM4 gene, an acyl-CoA thioesterase, is linked to diverticular disease.1[1], 7[2] Altered fatty acid metabolism, influenced by THEM4, could contribute to the low-grade inflammation often seen in this condition, but the specific role of this metabolite ratio is not defined.

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data