3-hydroxysebacate to 2-butenoylglycine

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Structure of 2-butenoylglycine
Metabolite Accession: GCST90200152
Name: 2-butenoylglycine
Hmdb Id: HMDB0341232
Super Pathway: NA
Sub Pathway: NA
Inchikey: WWJXRJJBIVSSNF

Associated Genomic Regions

Region: rs4507958

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.342
Position:
47383041
SE (Ratio):
0.029
Effect Allele:
T
Z-score (Ratio):
-11.703
Reference Allele:
A
-log10(P):
-71.171
MAF:
0.121
Beta (Num):
-0.247
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.096
SE (Den):
0.026
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism (acyl glycine).7[1]

Ratio Explanation:

The ratio may reflect competing fatty acid metabolism pathways, where CYP4B1's role in omega-oxidation influences the balance between 3-hydroxysebacate and 2-butenoylglycine formation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype is provided, so a causal link cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data