3-hydroxysebacate to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs4507958

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.287
Position:
47383041
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-12.269
Reference Allele:
A
-log10(P):
-78.003
MAF:
0.121
Beta (Num):
-0.247
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.041
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs28415528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.147
Position:
151879761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-8.833
Reference Allele:
G
-log10(P):
-41.425
MAF:
0.314
Beta (Num):
-0.106
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.040
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.10[1], 11[2], 12[3]

Ratio Explanation:

This ratio may reflect the balance between fatty acid omega-oxidation (numerator) and beta-oxidation (denominator), regulated by enzymes like those in the CYP4 family and THEM4.7[1], 6[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype associations were provided; therefore, a causal link between the genetic factors, the metabolite ratio, and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data