3-hydroxysebacate to trans-2-hexenoylglycine

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Structure of trans-2-hexenoylglycine
Metabolite Accession: GCST90200160
Name: trans-2-hexenoylglycine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: AAPHATPOQGNLOZ

Associated Genomic Regions

Region: rs6678639

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.318
Position:
47331966
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
-11.620
Reference Allele:
A
-log10(P):
-70.204
MAF:
0.119
Beta (Num):
-0.244
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.074
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4B1 CYP4A11 CYP4X1 EFCAB14 ATPAF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.5[1]

Denominator Metabolite Explanation:

Acyl-CoA metabolism, fatty acid metabolism.

Ratio Explanation:

The ratio may reflect altered fatty acid metabolism, but a direct enzymatic link between CYP4B1 and both metabolites is not established.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No direct link between the ratio and a phenotype is established in the provided information, although CYP4B1 variants are associated with some cancers.6[1]

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data