3-hydroxysebacate to glutamine conjugate of c7h12o2*

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11211403

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.318
Position:
47392855
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
-13.623
Reference Allele:
T
-log10(P):
-95.637
MAF:
0.120
Beta (Num):
-0.249
Novel Locus:
No
SE (Num):
0.025
Beta (Den):
0.070
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation; dicarboxylic acid metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Dicarboxylic acid metabolism; amino acid conjugation.10[1], 11[2]

Ratio Explanation:

The ratio may reflect the balance in omega-oxidation of different fatty acid precursors (C10 vs C7) by CYP4 enzymes and their subsequent metabolism/conjugation.7[1], 9[2], 12[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a link between the CYP4B1 variant, the metabolite ratio, and a clinical outcome cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data