3-hydroxysebacate to 3-hydroxybutyroylglycine**

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs4507958

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.316
Position:
47383041
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
-12.664
Reference Allele:
A
-log10(P):
-82.957
MAF:
0.121
Beta (Num):
-0.247
Novel Locus:
No
SE (Num):
0.024
Beta (Den):
0.070
SE (Den):
0.022
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.164
Position:
151879761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-9.291
Reference Allele:
G
-log10(P):
-45.628
MAF:
0.314
Beta (Num):
-0.106
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.058
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism (acyl glycine).5[1], 6[2], 7[3]

Ratio Explanation:

The ratio of 3-hydroxysebacate to 3-hydroxybutyroylglycine may reflect alterations in fatty acid oxidation and acyl-CoA metabolism, influenced by THEM4 activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered fatty acid metabolism due to THEM4 dysregulation may contribute to inflammation or tissue integrity changes in the intestine, increasing diverticular disease risk.8[1], 9[2], 10[3], 11[4], 12[5], 13[6]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data