3-hydroxysebacate to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs57025390

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.301
Position:
47412477
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-12.322
Reference Allele:
C
-log10(P):
-78.655
MAF:
0.118
Beta (Num):
-0.250
Novel Locus:
No
SE (Num):
0.025
Beta (Den):
0.051
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

Region: rs56078223

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.153
Position:
151898843
SE (Ratio):
0.017
Effect Allele:
G
Z-score (Ratio):
-8.764
Reference Allele:
T
-log10(P):
-40.812
MAF:
0.291
Beta (Num):
-0.108
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.045
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.6[1]

Denominator Metabolite Explanation:

Fatty acid metabolism and amino acid conjugation.7[1], 8[2]

Ratio Explanation:

The ratio likely reflects a balance between omega-oxidation of fatty acids (numerator) and their conjugation for clearance (denominator), influenced by CYP and THEM4 activity.9[1], 6[2], 10[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in *THEM4* likely alters fatty acid metabolism, reflected by the metabolite ratio, which may contribute to the low-grade inflammation characteristic of diverticular disease.3[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data