3-hydroxysebacate to glycine conjugate of c10h12o2*

Numerator Metabolite

Structure of 3-hydroxysebacate
Metabolite Accession: GCST90199704
Name: 3-hydroxysebacate
Hmdb Id: HMDB0000350
Super Pathway: NA
Sub Pathway: NA
Inchikey: OQYZCCKCJQWHIE

Denominator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11204915

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.207
Position:
151882826
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
-8.923
Reference Allele:
T
-log10(P):
-42.233
MAF:
0.397
Beta (Num):
-0.103
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.103
SE (Den):
0.018
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D S100A10 RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.9[1], 10[2]

Denominator Metabolite Explanation:

Glycine conjugation, xenobiotic metabolism.11[1]

Ratio Explanation:

The ratio may indicate the balance between fatty acid omega-oxidation, producing 3-hydroxysebacate, and a separate glycine conjugation pathway, potentially influenced by CYP4 and THEM4 activity.4[1], 1[2], 9[3], 10[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was provided, so no causal link between the genetic factors, the metabolite ratio, and a phenotype can be established from the available data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data