adrenate (22:4n6) to 3-hydroxymyristate

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.175
Position:
61588305
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-13.983
Reference Allele:
A
-log10(P):
-100.625
MAF:
0.344
Beta (Num):
-0.181
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.005
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/desaturation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio of adrenate (product) to 3-hydroxymyristate (unrelated pathway) may reflect FADS1/FADS2 desaturase activity, which is crucial for long-chain fatty acid synthesis.1[1], 4[2], 3[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting polyunsaturated fatty acid levels. This dysregulation of lipid metabolism is associated with an increased risk for cholelithiasis, dyslipidemia, and inflammatory conditions like asthma.8[1], 1[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data