adrenate (22:4n6) to docosatrienoate (22:3n3)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of docosatrienoate (22:3n3)
Metabolite Accession: GCST90199710
Name: docosatrienoate (22:3n3)
Hmdb Id: HMDB0002823
Super Pathway: NA
Sub Pathway: NA
Inchikey: WBBQTNCISCKUMU

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.403
Position:
61596633
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
-28.082
Reference Allele:
C
-log10(P):
-397.861
MAF:
0.346
Beta (Num):
-0.178
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.225
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

omega-6 PUFA biosynthesis

Denominator Metabolite Explanation:

omega-3 PUFA biosynthesis

Ratio Explanation:

The ratio of adrenate (an omega-6 PUFA) to docosatrienoate (an omega-3 PUFA) reflects the relative flux and efficiency of FADS1 in these competing pathways.4[1], 5[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter its enzymatic efficiency, which shifts the balance of omega-6 and omega-3 PUFAs.4[1], 6[2] This imbalance can influence lipid metabolism and inflammatory responses, potentially increasing the risk for associated phenotypes like hypercholesterolemia, cholelithiasis, and type 2 diabetes.2[3], 7[4], 6[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data