adrenate (22:4n6) to docosadienoate (22:2n6)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.154
Position:
61593005
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
-14.859
Reference Allele:
A
-log10(P):
-113.319
MAF:
0.346
Beta (Num):
-0.179
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.025
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis4[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis5[1]

Ratio Explanation:

The ratio of adrenate to docosadienoate reflects the efficiency of converting C22 fatty acids into more unsaturated forms, a process regulated by desaturase enzymes.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS cluster alters fatty acid metabolism, influencing the risk for disorders of lipoprotein metabolism, type 2 diabetes, and cholelithiasis.6[1], 7[2], 8[3], 9[4] These associations are likely driven by the role of FADS genes in modulating inflammatory and metabolic pathways.10[5], 8[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data