adrenate (22:4n6) to 10-nonadecenoate (19:1n9)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of 10-nonadecenoate (19:1n9)
Metabolite Accession: GCST90199728
Name: 10-nonadecenoate (19:1n9)
Hmdb Id: HMDB0013622
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBOWBNGUEWHNQZ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.197
Position:
61588305
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
-19.579
Reference Allele:
A
-log10(P):
-194.873
MAF:
0.344
Beta (Num):
-0.181
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.017
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1]

Denominator Metabolite Explanation:

Fatty Acid Metabolism4[1]

Ratio Explanation:

The ratio of adrenate (22:4n6) to 10-nonadecenoate (19:1n9) reflects the activity of fatty acid desaturase enzymes, where FADS1/FADS2 are key.5[1], 6[2], 7[3], 8[4]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the adrenate/10-nonadecenoate ratio, may alter fatty acid profiles in follicular cells, potentially contributing to the development of follicular cysts of the skin and subcutaneous tissue.9[1], 10[2], 11[3]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data