adrenate (22:4n6) to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.191
Position:
61593005
SE (Ratio):
0.010
Effect Allele:
G
Z-score (Ratio):
-20.046
Reference Allele:
A
-log10(P):
-204.145
MAF:
0.346
Beta (Num):
-0.179
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.012
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis3[1]

Denominator Metabolite Explanation:

Long-chain fatty acid metabolism4[1], 5[2], 6[3], 7[4]

Ratio Explanation:

The ratio reflects FADS desaturase activity, where higher levels indicate increased conversion of fatty acid precursors to adrenate relative to 10-heptadecenoate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster alter desaturase activity, influencing polyunsaturated fatty acid levels.8[1], 9[2] This dysregulated lipid metabolism is associated with an increased risk for cholelithiasis, type 2 diabetes, and disorders of lipoprotein metabolism.10[3], 11[4], 12[5], 2[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data