adrenate (22:4n6) to eicosenoate (20:1)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of eicosenoate (20:1)
Metabolite Accession: GCST90199744
Name: eicosenoate (20:1)
Hmdb Id: HMDB0002231,HMDB0062436
Super Pathway: NA
Sub Pathway: NA
Inchikey: BITHHVVYSMSWAG

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.198
Position:
61593005
SE (Ratio):
0.011
Effect Allele:
G
Z-score (Ratio):
-17.716
Reference Allele:
A
-log10(P):
-160.040
MAF:
0.346
Beta (Num):
-0.179
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.019
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid elongation.6[1]

Ratio Explanation:

The ratio of adrenate (22:4n6) to eicosenoate (20:1) reflects the efficiency of converting intermediate fatty acids into long-chain polyunsaturated fatty acids, a process influenced by FADS1/FADS2 activity.7[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS2 activity, which is genetically influenced, can disrupt the balance of fatty acids, potentially contributing to inflammatory conditions like follicular cysts of the skin.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:FADS2 1326-263-219-217-2025

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data