adrenate (22:4n6) to linolenate [alpha or gamma; (18:3n3 or 6)]

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of linolenate [alpha or gamma; (18:3n3 or 6)]
Metabolite Accession: GCST90199748
Name: linolenate [alpha or gamma; (18:3n3 or 6)]
Hmdb Id: HMDB0003073,HMDB0001388
Super Pathway: NA
Sub Pathway: NA
Inchikey: DTOSIQBPPRVQHS

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.191
Position:
61593005
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-14.600
Reference Allele:
A
-log10(P):
-109.485
MAF:
0.346
Beta (Num):
-0.179
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.012
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis3[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2]

Ratio Explanation:

The ratio of adrenate (product) to linolenate (precursor) reflects the enzymatic efficiency of the FADS-mediated fatty acid desaturation pathway.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are associated with altered enzyme activity, impacting levels of fatty acid products and precursors, which have been linked to variations in blood lipids and risk for cholelithiasis and hypercholesterolemia.1[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data