adrenate (22:4n6) to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.216
Position:
61569830
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-13.139
Reference Allele:
C
-log10(P):
-89.121
MAF:
0.339
Beta (Num):
-0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.033
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.4[1]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.5[1]

Ratio Explanation:

The ratio of adrenate to hexadecanedioate reflects the balance between polyunsaturated fatty acid synthesis and fatty acid degradation, influenced by FADS1/2 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants alter enzyme activity, impacting the adrenate to hexadecanedioate ratio.1[1], 2[2], 6[3] This altered lipid metabolism is linked to inflammatory conditions like inflammatory bowel disease and an increased risk of cardiovascular and metabolic diseases such as cholelithiasis and type 2 diabetes.7[4], 8[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data