adrenate (22:4n6) to (16 or 17)-methylstearate (a19:0 or i19:0)

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of (16 or 17)-methylstearate (a19:0 or i19:0)
Metabolite Accession: GCST90199887
Name: (16 or 17)-methylstearate (a19:0 or i19:0)
Hmdb Id: HMDB0037397
Super Pathway: NA
Sub Pathway: NA
Inchikey: YETXGSGCWODRAA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.195
Position:
61588305
SE (Ratio):
0.013
Effect Allele:
G
Z-score (Ratio):
-15.093
Reference Allele:
A
-log10(P):
-116.848
MAF:
0.344
Beta (Num):
-0.181
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.014
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis.9[1]

Ratio Explanation:

The ratio of adrenate to methylstearate reflects the activity of FADS enzymes, which are crucial for producing long-chain polyunsaturated fatty acids from their precursors.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 function, indicated by a lower adrenate to methylstearate ratio, is associated with altered lipid profiles and an increased risk for type 2 diabetes and cholelithiasis.1[1], 10[2], 5[3], 11[4], 12[5] This is likely due to changes in inflammatory and metabolic signaling.7[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data