adrenate (22:4n6) to n-oleoyltaurine

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of n-oleoyltaurine
Metabolite Accession: GCST90199912
Name: n-oleoyltaurine
Hmdb Id: HMDB0242113
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOGRJTUIKPMZEJ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.263
Position:
46870761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-15.015
Reference Allele:
C
-log10(P):
-115.658
MAF:
0.208
Beta (Num):
-0.024
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
0.239
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, Linoleic acid metabolism5[1], 9[2]

Denominator Metabolite Explanation:

Fatty acid amide metabolism, Endocannabinoid signaling10[1], 11[2], 12[3]

Ratio Explanation:

This ratio may reflect the balance between polyunsaturated fatty acid synthesis by FADS enzymes (numerator) and fatty acid amide degradation by FAAH (denominator).5[1], 6[2], 10[3], 11[4]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster and FAAH influence fatty acid metabolism, impacting lipid levels and inflammatory processes associated with cholelithiasis and hypercholesterolemia.13[1], 14[2], 15[3], 16[4], 17[5], 18[6], 19[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2/FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data