adrenate (22:4n6) to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.514
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-24.156
Reference Allele:
C
-log10(P):
-295.174
MAF:
0.339
Beta (Num):
-0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.331
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis.6[1]

Denominator Metabolite Explanation:

Phosphatidylcholine biosynthesis, PUFA metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects FADS1/FADS2 desaturase efficiency, comparing a downstream product (adrenate) to a lipid containing an upstream precursor (dihomo-linolenic acid), indicating PUFA metabolism balance.10[1], 11[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants alter PUFA metabolism, impacting levels of inflammatory mediators.12[1], 13[2], 14[3] This dysregulation is associated with chronic inflammatory and metabolic conditions like type 2 diabetes, hypercholesterolemia, and cholelithiasis, which are listed among the associated phenotypes.15[4], 16[5], 14[6], 17[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data