adrenate (22:4n6) to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.414
Position:
61569830
SE (Ratio):
0.027
Effect Allele:
T
Z-score (Ratio):
-15.232
Reference Allele:
C
-log10(P):
-118.959
MAF:
0.339
Beta (Num):
-0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.231
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

The ratio of adrenate to 1,2-dilinoleoyl-gpe reflects the activity of FADS1/FADS2, which convert linoleic acid (in the denominator) to precursors of adrenate (numerator).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 are associated with altered long-chain polyunsaturated fatty acid levels, which can influence inflammatory pathways and are linked to conditions like asthma, inflammatory bowel disease, and type 2 diabetes.5[1], 6[2], 7[3], 8[4], 9[5], 10[6], 11[7], 12[8], 13[9], 14[10], 15[11]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data