adrenate (22:4n6) to 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Metabolite Accession: GCST90200076
Name: 1-(1-enyl-stearoyl)-2-linoleoyl-gpe (p-18:0/18:2)*
Hmdb Id: HMDB0011376
Super Pathway: NA
Sub Pathway: NA
Inchikey: XVXISDREVDGQPX

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.350
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-15.056
Reference Allele:
C
-log10(P):
-116.280
MAF:
0.339
Beta (Num):
-0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.167
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Long-chain fatty acid biosynthesis

Denominator Metabolite Explanation:

Ether lipid metabolism, Glycerophospholipid metabolism

Ratio Explanation:

This ratio reflects FADS enzyme activity, comparing a downstream product (adrenate) to a plasmalogen containing a precursor fatty acid (linoleic acid).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, indicated by the metabolite ratio, impacts the balance of pro- and anti-inflammatory lipids. This dysregulation can causally lead to inflammatory conditions like follicular cysts and contribute to broader metabolic disturbances such as cholelithiasis and abnormal lipid profiles.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data