adrenate (22:4n6) to 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.286
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
-13.093
Reference Allele:
A
-log10(P):
-88.513
MAF:
0.344
Beta (Num):
-0.181
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.106
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

n-6 fatty acid biosynthesis5[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism6[1], 7[2]

Ratio Explanation:

The ratio reflects the activity of FADS1/FADS2, where higher activity leads to increased adrenate production relative to the glycerophosphoinositol pool, indicating altered fatty acid metabolism.1[1], 5[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, indicated by the adrenate to 1-palmitoyl-2-oleoyl-GPI ratio, influences the balance of pro- and anti-inflammatory fatty acids, impacting phenotypes like hypercholesterolemia, cholelithiasis, type 2 diabetes, and inflammatory diseases.8[1], 9[2], 10[3], 11[4], 12[5], 13[6], 14[7], 15[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data