adrenate (22:4n6) to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174549

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.335
Position:
61571382
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
-16.776
Reference Allele:
G
-log10(P):
-143.769
MAF:
0.304
Beta (Num):
-0.182
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.154
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic/Adrenic acid metabolism4[1]

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Carnitine)5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance of n-6 and n-3/6 fatty acid metabolism, which is influenced by FADS1 and FADS2 enzyme activity.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, reflected in the fatty acid ratio, influences the balance of pro- and anti-inflammatory lipid mediators and lipid metabolism.9[1], 7[2] This imbalance is linked to various inflammatory (asthma) and metabolic (hypercholesterolemia, cholelithiasis) diseases.10[3], 11[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data