adrenate (22:4n6) to tetradecadienoate (14:2)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Associated Genomic Regions

Region: rs61817724

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.156
Position:
151921111
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
12.245
Reference Allele:
A
-log10(P):
-77.704
MAF:
0.315
Beta (Num):
0.036
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.120
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

Region: rs174546

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.181
Position:
61569830
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
-14.556
Reference Allele:
C
-log10(P):
-108.852
MAF:
0.339
Beta (Num):
-0.183
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.002
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation

Ratio Explanation:

This ratio reflects fatty acid desaturase (FADS) activity, where higher values suggest increased conversion of shorter-chain fatty acids to the long-chain polyunsaturated fatty acid adrenate.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, impacting the adrenate to tetradecadienoate ratio.1[1], 8[2] This dysregulation of fatty acid metabolism is linked to inflammatory conditions and dyslipidemias, including IBD, asthma, and altered cholesterol levels, and is associated with valvular heart disease.9[3], 3[4], 10[5], 11[6], 12[7], 13[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data